The principal cytochrome P450 isoenzyme included appears being CYP2E1, with CYP1A2 and CYP3A4 as supplemental pathways. About 85% of the oral dose seems within the urine in 24 hours of administration, most since the glucuronide conjugate, with little amounts of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity facts.A really serious